TIMES OF INDIA 24 August 2009
A new study from University of California in Los Angeles suggests that piling on the
pounds can shrink brains of older people, making them more vulnerable to cognitive
problems.
According to Paul Thompson, brains of elderly obese people looked 16 years older than the
brains of leaner peers.
The research involving 94 people in their 70s showed that people with higher body mass
indexes had smaller brains on average, with the frontal and temporal lobes - important for
planning and memory, respectively - particularly affected.
While no one knows whether these people are more likely to develop dementia, a smaller
brain is indicative of destructive processes that can develop into dementia.
The team also found that the brains of the 51 overweight people were 6 per cent smaller
than those of their normal-weight counterparts, on average, and those of the 14 obese
people were 8 per cent smaller.
"The brains of overweight people looked eight years older than the brains of those
who were lean, and 16 years older in obese people," New Scientist quoted Thompson as
saying.
Thompson suggests that as increased body fat ups the chances of having clogged arteries,
which can reduce blood and oxygen flow to brain cells, the resulting reduction in
metabolism could cause brain cell death and the shrinking seen.
He said that exercise protects the very brain regions that had shrunk.
"The most strenuous kind of exercise can save about the same amount of brain tissue
that is lost in the obese," he said.
The findings appear in journal Human Brain Mapping.
http://timesofindia.indiatimes.com/life-style/health-fitness/health/Fatness-can-lead-to-brain-shrinkage/articleshow/4927664.cms
TIMES OF INDIA 22 August 2009
A doctor and a bio-technologist from Kerala have come up with an alternative treatment
for patients with critical spinal injuries and are now awaiting clearance from the
Drug Controller General of India (DCGI) to conduct human trials.
P.S. John, an orthopaedist, and C.S. Poulose, a bio-technologist, claim to have
successfully conducted trials on rats and rabbits at the department of neurosciences at
the Cochin University of Science and Technology from 2002 to 2008.
John, who retired as head of the department of orthopaedics from the Kottayam Medical
College, said: "We have developed a treatment protocol where one's own bone marrow
cells and neurotransmitter (a hormone like chemical messenger that carries impulses from
one nerve cell to the other) will be injected to the patient. Depending on the nature of
injury, the injection could last a month or for 12 months."
The laboratory tests were done under the supervision of Poulose, who is director of
neurosciences at the university.
Their work has by now been presented at many international conferences and is accepted for
publication in Current Science.
The study team has already secured a patent on their technique in the country.
Elaborating on the new method, John said: "Since we are using the patient's own bone
marrow, no ethical issues are involved. Moreover there will be no chance of adverse
reactions or rejection reactions. The neurotransmitter combination that is used to
modulate the bone marrow is naturally occurring amines in our system and hence will not
produce any untoward effects."
The study team has secured written consent from hundreds of patients willing to undergo
the clinical trials using the new technique.
Speaking to IANS, 27-year-old George K. Thomas, who has been bed-ridden after a road
accident in 2007, said: "I have tried various treatments and there is no change. I am
prepared to go through the clinical trials of this new technique. I really wish they get
the sanction for the trials."
http://timesofindia.indiatimes.com/life-style/health-fitness/health/Now-a-new-treatment-for-spinal-injuries/articleshow/4922259.cms